GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2076028 | 1 | rs6001214 | chr22:39149155 | LOC646851 | chr22:38974125-39052634:- | 0.18 | 4.61 | 5.15E-6 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs6001214 | chr22:39149155 | SUN2 | chr22:39130735-39190161:- | 0.15 | 3.55 | 0.000427 | Resting heart rate |
| THCA | cis | rs6494537 | 1 | rs600193 | chr15:65729409 | DPP8 | chr15:65737999-65810035:- | 0.09 | 3.86 | 0.000126 | Mean corpuscular hemoglobin |
| THCA | cis | rs6494537 | 1 | rs600193 | chr15:65729409 | SLC24A1 | chr15:65903704-65953256:+ | 0.16 | 3.79 | 0.000167 | Mean corpuscular hemoglobin |
| THCA | cis | rs2200578 | 1 | rs60025964 | chr2:99880577 | LIPT1 | chr2:99771418-99779611:+ | 0.2 | 3.89 | 0.000116 | IgG glycosylation |
| THCA | cis | rs13393800 | 1 | rs60029373 | chr2:233456262 | EIF4E2 | chr2:233415357-233448349:+ | -0.23 | -4.34 | 1.72E-5 | Height |
| THCA | cis | rs1027730 | 1 | rs60030116 | chr8:94071004 | C8orf83 | chr8:93895865-94029901:- | 0.27 | 4.43 | 1.19E-5 | Attention deficit hyperactivity disorder |
| THCA | cis | rs4820539 | 1 | rs6003518 | chr22:23471533 | GNAZ | chr22:23412669-23467221:+ | -0.27 | -5.8 | 1.23E-8 | Bone mineral density |
| THCA | cis | rs4038131 | 1 | rs60043652 | chr2:17778944 | GEN1 | chr2:17935162-17966632:+ | 0.51 | 6.86 | 2.08E-11 | Psychosis and Alzheimer's disease |
| THCA | cis | rs1930961 | 1 | rs6004667 | chr22:25874464 | CRYBB2 | chr22:25615612-25627836:+ | -0.83 | -12.71 | 4.24E-32 | Bipolar disorder with mood-incongruent psychosis |
| THCA | cis | rs1930961 | 1 | rs6004669 | chr22:25875803 | CRYBB2 | chr22:25615612-25627836:+ | 0.82 | 12.49 | 3.48E-31 | Bipolar disorder with mood-incongruent psychosis |
| THCA | cis | rs1930961 | 1 | rs6004673 | chr22:25885353 | CRYBB2 | chr22:25615612-25627836:+ | 0.75 | 12.17 | 7.22E-30 | Bipolar disorder with mood-incongruent psychosis |
| THCA | cis | rs10816533 | 1 | rs60072763 | chr9:99547980 | FAM22G | chr9:99690592-99704572:+ | 0.98 | 7.96 | 1.22E-14 | Height |
| THCA | cis | rs10816533 | 1 | rs60072763 | chr9:99547980 | HIATL2 | chr9:99695549-99775862:- | 0.71 | 5.74 | 1.66E-8 | Height |
| THCA | cis | rs10816533 | 1 | rs60072763 | chr9:99547980 | LOC441454 | chr9:99671357-99672736:+ | 0.44 | 3.92 | 0.0001 | Height |